Colon Adenocarcinoma Disease

You will have the opportunity to describe the pathophysiology and pharmacological management for a person suffering from colon adenocarcinoma. We would like you to show your understanding by making explicit the links between pathophysiology, clinical manifestations, and pharmacological management of your person’s disease. When preparing your presentation, assume that your target audience is health professionals (e.g., nurses, paramedics, midwives; all of which should have roughly the same base knowledge). Your answers to the questions below will be used to grade the ‘depth’, ‘accuracy’, and ‘clarity’ sections of your vodcast assignment (see marking rubric provided at the end of this document). At the beginning of your Vodcast, you need to set the scene within the first minute — i.e., tell us about your person, and then proceed to answer the following questions.

You must answer all 3 questions below:

Question 1. Answer both parts (a) and (b).
(a) Describe the physiological structure and function of the cells/tissues where colon adenocarcinoma originates from.
(b) Describe at least five risk factors for colon adenocarcinoma and discuss strategies used for prevention and early diagnosis of this type of tumor.

Question 2. Answer both parts (a) and (b).
(a) Describe how mutations in either a proto-oncogene or tumor suppressor gene contribute to the initiation of colon adenocarcinoma.
(b) Discuss how metastases can occur in colon adenocarcinoma and describe the most common locations where this type of metastatic tumor implants.

Question 3.
Explain the mechanism of action of the chemotherapy used to treat colon adenocarcinoma.